- What’s the matter?
- What’s wrong?
- Are you all right?
- You look a bit down.
(= a little sad) - Is there anything I can do to help?
- Cheer up! / Chin up!
- It’s not so bad.
- Everything will be OK.
- Look on the bright side.
(= consider the positive aspects) - It’s not the end of the world.
(this phrase is used when someone is upset about something small and trivial)